Mechanism of cough reflex

1. Deep inspiration, closed glottis
2. Increased intrapleural pressure then glottis opens suddenly with outflow of air at high velocity
3. Leads to the expulsion of irritants from mouth only

1. Receptors in nose, paranasal sinuses, pharynx, trachea, pleura, diaphragm, perichondrium, stomach, ex.auditory canal and tymphanic membrane
2. Stimulus pass via V,IX,X cranial nerves and phrenic nerves. And reach to
3. Cough centre in medulla
4. Efferent nerves from medullary centre, X cranial nerve, phrenic nerve, spinal motor nerve
5. Activation of primary and accessory respiratory muscles

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