Lipoprotein Metabolism : Animation video

1. Consists of non-polar core (Mainly Triglycerides and cholesteryl esters)
2. A single surface layer of amphipathic phospholipids and cholesterol
3. Protein moiety are known as Apoprotein or Apolipoprotein
4. Protein and lipid contents vary

• Synthesised in intestine
• Transport TAG (Triacylglycerol) to tissues and deliver remaining cholesterol & cholesterol ester to the liver.

• VLDL is synthesised in liver and converted to LDL which contain an increased proportion of cholesterol & cholesteryl ester (due to loss of TAG).
• Transport TAG and cholesterol from liver to tissues.
• Cholesterol in LDL referred to as “bad cholesterol” since LDLs are implicated in atherosclerosis

• HDL carries “used” cholesterol (as CE) back to the liver. Also donate some CE to circulating VLDL for redistribution to tissues.
• HDL taken up by liver and degraded. The cholesterol is excreted as bile salts or repackaged in VLDL for distribution to tissues.
• Cholesterol synthesis in the liver is regulated by the cholesterol arriving through HDL (and dietary cholesterol returned by chylomicron remnants).
• Cholesterol (CE) in HDL is referred to as “good cholesterol”.

You Might Also Like